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RGS Protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RGS Protein (4) Calcium Channel (1) Epigenetic Reader Domain (1) Histone Acetyltransferase (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1) Neurological Disease (3)

5

Inhibitors & Agonists

4

Recombinant Proteins

1

Antibodies

Targets Recommended: RGS Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CCG 203769	RGS Protein	Neurological Disease
CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gα_o protein-protein interaction in vitro with an IC₅₀ of 17 nM.

CCG-50014 1 Publications Verification	RGS Protein	Inflammation/Immunology
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC₅₀ =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .

HY-70075

CCG-63808

2 Publications Verification

RGS Protein Cancer

CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.

BMS-192364	RGS Protein Calcium Channel	Neurological Disease
BMS-192364 is targeting the G_α-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert *RGS*-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux .

PF-CBP1 hydrochloride 1 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Neurological Disease
PF-CBP1 hydrochloride is a highly selective inhibitor of the *CREB binding protein* bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with IC₅₀** of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β, IL-6 and IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates RGS4* expression* cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinson's disease, et al .

Species:	Human (4)
Tag:	His (2) Tag Free (1) GST (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

	RGS5 Protein, Human (His) Regulator of G-Protein signaling 5; RGS5	Human	E. coli
	RGS5, an adept signal transduction modulator, enhances G protein alpha subunit GTPase activity, promoting their transition to the inactive GDP-bound state. Interacting with G(i)-alpha and G(o)-alpha, it selectively excludes G(s)-alpha, highlighting its precise role in regulating specific G protein subunits and fine-tuning cellular signaling pathways. RGS5 Protein, Human (His) is the recombinant human-derived RGS5 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RGS5 Protein, Human (His) is 181 a.a., with molecular weight of ~25 kDa.

	RGS14 Protein, Human RGS14; Regulator of G-Protein signaling 14; RGS14	Human	E. coli
	The RGS14 protein complexly regulates G protein-coupled receptor signaling by enhancing the GTPase activity of specific α subunits and acting as a GDP dissociation inhibitor (GDI). It exhibits GDI activity on GNAI1 and GNAI3 but not on GNAI2 and GNAO1. RGS14 Protein, Human is the recombinant human-derived RGS14 protein, expressed by E. coli , with tag free. The total length of RGS14 Protein, Human is 565 a.a., .

	RGS14 Protein, Human (His) RGS14; Regulator of G-Protein signaling 14; RGS14	Human	E. coli
	The RGS14 protein complexly regulates G protein-coupled receptor signaling by enhancing the GTPase activity of specific α subunits and acting as a GDP dissociation inhibitor (GDI). It exhibits GDI activity on GNAI1 and GNAI3 but not on GNAI2 and GNAO1. RGS14 Protein, Human (His) is the recombinant human-derived RGS14 protein, expressed by E. coli , with N-6*His labeled tag. The total length of RGS14 Protein, Human (His) is 565 a.a., .

	RGS17 Protein, Human (GST) RGS17; RGSZ2; RGS-17; hRGS17; regulator of G-Protein signaling 17; OTTHUMP00000017460	Human	E. coli
	RGS17 protein centrally regulates G protein-coupled receptor signaling, inhibiting signal transduction by enhancing G protein alpha subunit GTPase activity. It selectively binds to GNAZ and GNAI2 subunits, accelerating GTPase activity and modulating signaling. Additionally, RGS17 negatively regulates mu-opioid receptor-mediated G-protein activation, forming complexes with receptors and G(alpha)z/i2 subunits. Molecular interactions include binding to OPRM1 and interacting with HINT1, highlighting its role in a complex regulatory network for diverse G protein-dependent signaling pathways. RGS17 Protein, Human (GST) is the recombinant human-derived RGS17 protein, expressed by E. coli, with N-GST labeled tag. The total length of RGS17 Protein, Human (GST) is 210 a.a., with molecular weight of 51.4 kDa.

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